Assessing carpal tunnel syndrome with magnetoneurography

Clin Neurophysiol. 2022 Jul;139:1-8. doi: 10.1016/j.clinph.2022.03.021. Epub 2022 Apr 9.


Objective: To measure the neuromagnetic fields of carpal tunnel syndrome patients after electrical digital nerve stimulation and evaluate median nerve function with high spatial resolution.

Methods: A superconducting quantum interference device magnetometer system was used to record neuromagnetic fields at the carpal tunnel after electrical stimulation of the middle digital nerve in 10 hands of nine patients with carpal tunnel syndrome. The patients were diagnosed based on symptoms (numbness, tingling, and pain) supported by a positive Phalen or Tinel sign. A novel technique was applied to remove stimulus-induced artifacts, and current distributions were calculated using a spatial filter algorithm and superimposed on X-ray.

Results: In 6 of the 10 hands, the amplitude of the inward current waveform attenuated to <70% or the nerve conduction velocity was <40 m/s. The results of conventional nerve conduction studies were normal for two of these six hands. All four hands that could not be diagnosed by magnetoneurography had severe carpal tunnel syndrome superimposed on peripheral neuropathy secondary to comorbidities.

Conclusions: Technical improvements enabled magnetoneurography to noninvasively visualize the electrophysiological nerve activity in carpal tunnel syndrome patients.

Significance: Magnetoneurography may have the potential to contribute to the detailed diagnosis of various peripheral nerve disorders.

Keywords: Carpal tunnel syndrome; Conduction velocity; Digital nerve; Magnetoneurography; Median nerve; Nerve conduction study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carpal Tunnel Syndrome* / diagnosis
  • Humans
  • Median Nerve
  • Neural Conduction / physiology
  • Peripheral Nervous System Diseases*
  • Wrist