Pre-pregnancy obesity and the risk of peripartum cardiomyopathy: A systematic review and meta-analysis

Indian Heart J. 2022 May-Jun;74(3):235-238. doi: 10.1016/j.ihj.2022.04.009. Epub 2022 Apr 28.

Abstract

The outcome of this review is to assess the association between pre-pregnancy obesity and PPCM incidence. There were a total of 5.373.581 participants were included in this study. Pre-pregnancy obesity was significantly associated with PPCM incidence compared to normal-weight subjects (OR = 1.79 (1.16,2.76); p = 0.008; I2 = 59%, Pheterogeneity = 0.04). The sub-group analysis showed that pre-pregnancy women with obesity class I (OR = 1.58 (1.20,2.07); p = 0.001; I2 = 0%, Pheterogeneity = 0.64) and class II and III (OR = 2.65 (2.04,3.45); p < 0.001; I2 = 6%, Pheterogeneity = 0.36) was significantly associated with PPCM incidence compared to normal-weight subjects.

Keywords: Body mass index; Peripartum cardiomyopathy; Pre-pregnancy obesity.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Cardiomyopathies* / complications
  • Cardiomyopathies* / diagnosis
  • Cardiomyopathies* / epidemiology
  • Female
  • Humans
  • Incidence
  • Obesity / complications
  • Obesity / epidemiology
  • Peripartum Period
  • Pregnancy
  • Pregnancy Complications, Cardiovascular* / epidemiology