Association between Maternal Birth Weight and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Mehdi Shokri; Mahsa Rizebandi; Parviz Karimi; Gholamreza Badfar; Marzieh Parizad Nasirkandy; Gholamreza Kalvandi; Shoboo Rahmati

doi:10.1007/s13224-022-01645-8

Association between Maternal Birth Weight and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

J Obstet Gynaecol India. 2022 Apr;72(2):125-133. doi: 10.1007/s13224-022-01645-8. Epub 2022 Apr 7.

Authors

Mehdi Shokri¹, Mahsa Rizebandi², Parviz Karimi¹, Gholamreza Badfar³, Marzieh Parizad Nasirkandy⁴, Gholamreza Kalvandi⁵, Shoboo Rahmati⁶

Affiliations

¹ Department of Pediatrics, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
² Department of Internal Medicine, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
³ Department of Pediatric, Faculty of Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.
⁴ Department of Obstetrics and Gynecology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Associate Professor of Pediatrics Gastroenterology, Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran.
⁶ Student Research Committee, Department of Epidemiology, Kerman University of Medical Sciences, Kerman, Iran.

Abstract

Background and aims: Gestational diabetes mellitus is one of the most important issue related to health status of mothers and their children throughout life. This meta-analysis has been conducted to assess relationship between maternal birth weight and gestational diabetes.

Methods and results: This article is written using PRISMA guideline for systematic review and meta-analysis. We searched epidemiological studies without a time limit from following databases-Scopus, PubMed, Science Direct, Embase, Web of Science, CINAHL, Cochrane, EBSCO, and Google Scholar search engine using MESH keywords. Heterogeneity was determined using the Cochran Q test and I ² index. Data were analyzed using comprehensive meta-analysis, version 2. The significance level of the tests was considered as P < 0.05.

Results: The result of combining ten studies with a sample size of 228,409 cases using a fixed-effect model showed that low maternal birth weight increased the risk of gestational diabetes mellitus (1.71 [95% CI 1.43-2.06, P < 0.001]). In addition, the result of combining nine studies with a sample size of 227,805 cases using a random-effects model showed that macrosomia did not increase the risk of gestational diabetes mellitus, and there was no significant relationship between them (1.04 [95% CI 0.79-1.38; p value: 0.730]).

Conclusion: The results of this systematic review and meta-analysis showed that low maternal birth weight could be a risk factor for gestational diabetes in adulthood.

Keywords: Gestational diabetes; Maternal birth weight; Meta-analysis; Systematic review.

Publication types

Review