Effect of haloperidol and d-amphetamine on cerebral tyramine and octopamine levels

Eur J Pharmacol. 1978 Jul 1;50(1):79-82. doi: 10.1016/0014-2999(78)90256-x.

Abstract

The administration of d-amphetamine or haloperidol produced a marked reduction in the rat striatum concentration of p-tyramine, an effect that was not observed in the mesolimbic system. However, the administration of d-amphetamine to haloperidol-pretreated animals produced in both brain areas a marked reduction in p-tyramine levels. Furthermore, this latter treatment produced a marked increase in the m-tyramine levels in both brain regions. Hypothalamic p-octopamine levels were reduced by d-amphetamine, but not by haloperidol or haloperidol in the presence of d-amphetamine.

MeSH terms

  • Animals
  • Brain Chemistry / drug effects*
  • Dextroamphetamine / pharmacology*
  • Haloperidol / pharmacology*
  • Male
  • Octopamine / metabolism*
  • Rats
  • Time Factors
  • Tyramine / metabolism*

Substances

  • Octopamine
  • Haloperidol
  • Dextroamphetamine
  • Tyramine