Adverse effects of long-term Levothyroxine therapy in Subclinical Hypothyroidism

Ann Med Surg (Lond). 2022 Apr 4:76:103503. doi: 10.1016/j.amsu.2022.103503. eCollection 2022 Apr.


Levothyroxine, also known as L-thyroxine, is a manufactured form of the thyroid hormone thyroxine which is considered to be a gold-standard therapy for treating an underactive thyroid gland (hypothyroidism). Some experts highlight benefits of LT4 replacement therapy, others specify the harmful effects of it, in regards to treating subclinical hypothyroidism. With respect to current guidelines for the consistent dosing of levothyroxine for treating hypothyroidism, we aim to highlight limitations of long-term use of Levothyroxine therapy in SCH. Apropos of the studies published to date, we look into the appropriate dosing of Levothyroxine in SCH by physicians.