The management of gallstones in primary care is challenging. After diagnosis, the GP has to decide which symptomatic patients will profit from referral for surgery. This is complicated, as many patients will continue to have symptoms also after surgery. A prediction model can support the GP in giving a more personalized advice. The prediction model is based on outcome data from randomized trials. These data helps GPs to have the right conversation with patients by predicting the probability of persisting pain after surgery. GPs should be more cautious in case of young age, heartburn, low pain scores and a history of abdominal surgery.