Complications of corneal collagen cross-linking

Indian J Ophthalmol. 2022 May;70(5):1466-1474. doi: 10.4103/ijo.IJO_1595_21.


Corneal collagen cross-linking (CXL) is an effective treatment for arresting progression in patients with keratoconus. CXL was approved by United States Food and Drug Administration for the treatment of progressive keratoconus in 2016. It is a relatively safe procedure with a low complication rate. As this approach becomes more popular, it is paramount to be familiar with the potential complications associated with the procedure and its management. This article aims to report and review the complications of CXL for the treatment of keratoconus and post-LASIK ectasia.

Keywords: CXL; Complications; corneal collagen cross-linking; epi-on CXL; keratoconus; post-LASIK ectasia; transepithelial cross-linking.

Publication types

  • Review

MeSH terms

  • Collagen / therapeutic use
  • Cross-Linking Reagents / therapeutic use
  • Humans
  • Keratoconus* / diagnosis
  • Keratoconus* / drug therapy
  • Photochemotherapy* / methods
  • Ultraviolet Rays
  • United States


  • Cross-Linking Reagents
  • Collagen