Effects of supplemental chromium on patients with symptoms of reactive hypoglycemia

Metabolism. 1987 Apr;36(4):351-5. doi: 10.1016/0026-0495(87)90206-x.

Abstract

To determine if chromium (Cr) is involved in hypoglycemia, eight female patients with symptoms of hypoglycemia were supplemented with 200 micrograms of Cr as chromic chloride for three months in a double-blind crossover experimental design study. Chromium supplementation alleviated the hypoglycemic symptoms and significantly raised the minimum serum glucose values observed two to four hours following a glucose load. Insulin binding to red blood cells and insulin receptor number also improved significantly during Cr supplementation. These data suggest that impaired Cr nutrition and/or metabolism may be a factor in the etiology of hypoglycemia.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / metabolism
  • C-Peptide / metabolism
  • Chromium / administration & dosage
  • Chromium / therapeutic use*
  • Double-Blind Method
  • Female
  • Glucose Tolerance Test
  • Humans
  • Hypoglycemia / drug therapy*
  • Insulin / blood
  • Middle Aged
  • Receptor, Insulin / metabolism

Substances

  • Blood Glucose
  • C-Peptide
  • Insulin
  • Chromium
  • Receptor, Insulin