Effects of supplemental chromium on patients with symptoms of reactive hypoglycemia

Metabolism. 1987 Apr;36(4):351-5. doi: 10.1016/0026-0495(87)90206-x.


To determine if chromium (Cr) is involved in hypoglycemia, eight female patients with symptoms of hypoglycemia were supplemented with 200 micrograms of Cr as chromic chloride for three months in a double-blind crossover experimental design study. Chromium supplementation alleviated the hypoglycemic symptoms and significantly raised the minimum serum glucose values observed two to four hours following a glucose load. Insulin binding to red blood cells and insulin receptor number also improved significantly during Cr supplementation. These data suggest that impaired Cr nutrition and/or metabolism may be a factor in the etiology of hypoglycemia.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / metabolism
  • C-Peptide / metabolism
  • Chromium / administration & dosage
  • Chromium / therapeutic use*
  • Double-Blind Method
  • Female
  • Glucose Tolerance Test
  • Humans
  • Hypoglycemia / drug therapy*
  • Insulin / blood
  • Middle Aged
  • Receptor, Insulin / metabolism


  • Blood Glucose
  • C-Peptide
  • Insulin
  • Chromium
  • Receptor, Insulin