Congenital cataract with microcornea and Peters' anomaly as expressions of one autosomal dominant gene

Ophthalmic Paediatr Genet. 1986 Dec;7(3):187-94. doi: 10.3109/13816818609004137.


Hereditary congenital cataract is a well recognized but heterogeneous group of disorders; the cataracts may occur alone, or with other ocular or systemic abnormalities, and with all three common modes of inheritance. Peters' anomaly has usually been regarded as a sporadic condition with an insignificant risk of recurrence. A family is described in which congenital cataracts with microcornea, and Peters' anomaly, appear to be variable expressions of a generalized anterior segment disorder inherited as an autosomal dominant condition.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cataract / genetics*
  • Cataract / pathology
  • Child
  • Chromosome Aberrations / genetics*
  • Chromosome Aberrations / pathology
  • Chromosome Disorders
  • Cornea / abnormalities*
  • Cornea / pathology
  • Corneal Opacity / genetics*
  • Corneal Opacity / pathology
  • Corneal Transplantation
  • Gene Expression Regulation
  • Genes, Dominant*
  • Humans
  • Male
  • Pedigree
  • Tissue Adhesions