Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension

Pulm Circ. 2022 Mar 23;12(1):e12056. doi: 10.1002/pul2.12056. eCollection 2022 Jan.


BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.

Keywords: BMPR2; angiogenesis; hypoxia; pulmonary hypertension.