Daratumumab in AL amyloidosis

Blood. 2022 Dec 1;140(22):2317-2322. doi: 10.1182/blood.2021014613.


Light-chain amyloidosis has come far, with the first treatment getting regulatory approval in 2021. Daratumumab-based regimens achieve deep hematologic and organ responses, offering a new therapeutic backbone. Early identification, correct fibril typing, challenges of the very advanced patient, and lack of therapies to remove amyloid deposits remain under study, but are, as yet, elusive. We review the progress of treatment in AL amyloidosis, the impact of daratumumab, and the next steps after treatment.

Publication types

  • Review

MeSH terms

  • Amyloidosis* / drug therapy
  • Antibodies, Monoclonal / therapeutic use
  • Humans
  • Immunoglobulin Light-chain Amyloidosis* / drug therapy


  • daratumumab
  • Antibodies, Monoclonal