Nonallograft Complications of Lung Transplantation

Tany Thaniyavarn; Harpreet Singh Grewal; Hilary J Goldberg; Selim M Arcasoy

doi:10.1016/j.thorsurg.2022.01.004

Nonallograft Complications of Lung Transplantation

Thorac Surg Clin. 2022 May;32(2):243-258. doi: 10.1016/j.thorsurg.2022.01.004.

Authors

Tany Thaniyavarn¹, Harpreet Singh Grewal², Hilary J Goldberg³, Selim M Arcasoy²

Affiliations

¹ Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, PBB Clinic 3, Boston, MA 02115, USA. Electronic address: tthaniyavarn@bwh.harvard.edu.
² Lung Transplant Program, Columbia University Irving Medical Center, 622 W 168th Street, PH 14E, Suite 104, New York, NY 10032, USA.
³ Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, PBB Clinic 3, Boston, MA 02115, USA.

PMID: 35512942
DOI: 10.1016/j.thorsurg.2022.01.004

Abstract

Long-term exposure to immunosuppressive therapy may exacerbate pre-existing medical comorbidities or result in the development of new chronic medical conditions after lung transplantation. This article focuses on common nonallograft complications with the highest impact on short- and long-term outcomes after transplantation. These include diabetes mellitus, hypertension, dyslipidemia, kidney disease (acute and chronic), and malignancy. We discuss evidence-based strategies for the prevention, diagnosis, and management of these nonallograft complications in this article.

Keywords: Complications; Immunosuppression; Lung transplantation; Nonallograft.

Publication types

Review

MeSH terms

Humans
Immunosuppression Therapy
Immunosuppressive Agents*
Lung Transplantation* / adverse effects
Postoperative Complications

Substances

Immunosuppressive Agents