[Protective effect of forskolin in acetylcholine provocation in healthy probands. Comparison of 2 doses with fenoterol and placebo]

Wien Med Wochenschr. 1986 Dec 31;136(23-24):637-41.
[Article in German]


Forskolin, a potent adenylate cyclase activating diterpene-derivative, isolated from the Indian plant Coleus forskohlii, was tested double-blind and cross-over in 12 healthy volunteers (nonsmokers) by whole body plethysmography. All drugs were administered by metered dose inhalers. The bronchodilating effect (after 5 minutes) was as good as following fenoterol. At the beginning (after 3 and 5 minutes) the protective effect against inhaled acetylcholine was as good as following fenoterol while later on (after 15 and 30 minutes) fenoterol resulted in a stronger action.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Acetylcholine*
  • Adult
  • Airway Resistance / drug effects
  • Bronchial Provocation Tests*
  • Clinical Trials as Topic
  • Colforsin / pharmacology*
  • Double-Blind Method
  • Female
  • Fenoterol / pharmacology*
  • Humans
  • Male
  • Random Allocation


  • Colforsin
  • Fenoterol
  • Acetylcholine