Activation of c-ras oncogenes by mutations and amplification

Ann Clin Res. 1986;18(5-6):297-303.

Abstract

About 15% of all human tumours, including carcinomas, sarcomas, melanomas and leukaemias, contain c-ras oncogenes, which can be detected by a variety of methods. The activating lesion in the c-ras oncogenes is most often a point mutation affecting certain critical amino acid residues of its protein product. The clinical significance of c-ras oncogenes is not yet clear.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic*
  • Gene Amplification*
  • Gene Expression Regulation
  • Humans
  • Mutation*
  • Oncogenes*
  • Proto-Oncogenes