The NLRP3 inflammasome in fibrosis and aging: The known unknowns

Yanqing Liu; Xuezeng Xu; Wangrui Lei; Yuxuan Hou; Yan Zhang; Ran Tang; Zhi Yang; Ye Tian; Yanli Zhu; Changyu Wang; Chao Deng; Shaofei Zhang; Yang Yang

doi:10.1016/j.arr.2022.101638

The NLRP3 inflammasome in fibrosis and aging: The known unknowns

Ageing Res Rev. 2022 Aug:79:101638. doi: 10.1016/j.arr.2022.101638. Epub 2022 May 5.

Authors

Yanqing Liu¹, Xuezeng Xu², Wangrui Lei¹, Yuxuan Hou¹, Yan Zhang¹, Ran Tang¹, Zhi Yang¹, Ye Tian¹, Yanli Zhu¹, Changyu Wang¹, Chao Deng³, Shaofei Zhang⁴, Yang Yang⁵

Affiliations

¹ Department of Cardiology, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. School of Life Sciences and Medicine, Northwest University, Xi'an, China.
² Department of Cardiology, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, Xi'an, China.
³ Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
⁴ Department of Cardiology, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. School of Life Sciences and Medicine, Northwest University, Xi'an, China. Electronic address: sfzhangnw@163.com.
⁵ Department of Cardiology, Xi'an No.3 Hospital, School of Life Sciences and Medicine, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. School of Life Sciences and Medicine, Northwest University, Xi'an, China. Electronic address: yang200214yy@163.com.

PMID: 35525426
DOI: 10.1016/j.arr.2022.101638

Abstract

Aging-related diseases such as cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases are often accompanied by fibrosis. The NLRP3 inflammasome triggers the inflammatory response and subsequently promotes fibrosis through pathogen-associated molecular patterns (PAMPs). In this review, we first introduce the general background and specific mechanism of NLRP3 in fibrosis. Second, we investigate the role of NLRP3 in fibrosis in different organs/tissues. Third, we discuss the relationship between NLRP3 and fibrosis during aging. In summary, this review describes the latest progress on the roles of NLRP3 in fibrosis and aging and reveals the possibility of NLRP3 as an antifibrotic and anti-aging treatment target.

Keywords: Aging; Fibrosis; NLRP3.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging* / pathology
Fibrosis* / metabolism
Fibrosis* / prevention & control
Humans
Inflammasomes* / metabolism
NLR Family, Pyrin Domain-Containing 3 Protein* / metabolism

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein