Evaluation of the safety and effectiveness of tubal inflammatory drugs in patients with incomplete tubal obstruction after four-dimensional hysterosalpingo-contrast-sonography examination

BMC Pregnancy Childbirth. 2022 May 7;22(1):395. doi: 10.1186/s12884-022-04722-y.

Abstract

Background: To investigate the safety and effectiveness of tubal inflammatory drugs in patients with incomplete tubal obstruction of at least one side after four-dimensional hysterosalpingo-contrast-sonography (4D-HyCoSy) examination.

Methods: Two hundred fifteen cases of tubal incomplete obstruction were diagnosed by ultrasonography from February 2019 to November 2020.According to retrospective analysis,the patients in this study were divided into experimental and control groups; the experimental group combined with salpingitis drugs, and the control group received blank control. Basic information, degree of pain, postoperative complications, and pregnancy rate were then compared between the two groups.

Results: Compared with the control group, there was no significant difference in the basic information; in preoperative, intraoperative, or postoperative pain; or in postoperative complications (P > 0.05). The cumulative pregnancy rate of the experimental group (26.8%) was statistically different from that of the control group (14.4%) (P < 0.05).

Conclusions: We observed that for infertile patients with incomplete obstruction of at least one fallopian tube as diagnosed by contrast-enhanced ultrasonography, salpingitis-treatment drugs effectively improved the pregnancy rate postoperatively, with high effectiveness and safety. This regimen is thus worthy of further investigation and promotion in the future.

Keywords: Four-dimensional hysterosalpingo-contrast-sonography (4D-HyCoSy); Incomplete tubal obstruction; Tubal inflammatory drugs.

MeSH terms

  • Contrast Media / adverse effects
  • Fallopian Tube Diseases* / complications
  • Fallopian Tube Diseases* / diagnostic imaging
  • Fallopian Tube Patency Tests / adverse effects
  • Fallopian Tube Patency Tests / methods
  • Fallopian Tubes / diagnostic imaging
  • Female
  • Humans
  • Hysterosalpingography / adverse effects
  • Hysterosalpingography / methods
  • Imaging, Three-Dimensional / methods
  • Infertility, Female* / diagnosis
  • Infertility, Female* / etiology
  • Postoperative Complications / etiology
  • Pregnancy
  • Retrospective Studies
  • Salpingitis* / complications
  • Salpingitis* / diagnostic imaging
  • Ultrasonography / methods

Substances

  • Contrast Media