Curcumin can improve Parkinson's disease via activating BDNF/PI3k/Akt signaling pathways

Food Chem Toxicol. 2022 Jun;164:113091. doi: 10.1016/j.fct.2022.113091. Epub 2022 May 6.


Parkinson's disease is a common progressive neurodegenerative disease, and presently has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in neurodegenerative diseases and other different pathological settings. The brain-derived neurotrophic factor (BDNF) and phosphatidylinositol 3 kinase (PI3k)/protein kinase B (Akt) signaling pathways are significantly involved nerve regeneration and anti-apoptotic activities. Currently, relevant studies have confirmed that curcumin has an optimistic impact on neuroprotection via regulating BDNF and PI3k/Akt signaling pathways in neurodegenerative disease. Here, we summarized the relationship between BDNF and PI3k/Akt signaling pathway, the main biological functions and neuroprotective effects of curcumin via activating BDNF and PI3k/Akt signaling pathways in Parkinson's disease. This paper illustrates that curcumin, as a neuroprotective agent, can delay the progression of Parkinson's disease by protecting nerve cells.

Keywords: Brain-derived neurotrophic factor; Curcumin; Neurodegenerative diseases; PI3k/Akt signaling pathway; Parkinson's disease.

Publication types

  • Review

MeSH terms

  • Brain-Derived Neurotrophic Factor / metabolism
  • Curcumin* / pharmacology
  • Curcumin* / therapeutic use
  • Humans
  • Neurodegenerative Diseases*
  • Neuroprotective Agents* / pharmacology
  • Neuroprotective Agents* / therapeutic use
  • Parkinson Disease* / drug therapy
  • Parkinson Disease* / metabolism
  • Phosphatidylinositol 3-Kinase / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism
  • Signal Transduction


  • Brain-Derived Neurotrophic Factor
  • Neuroprotective Agents
  • Phosphatidylinositol 3-Kinase
  • Proto-Oncogene Proteins c-akt
  • Curcumin