Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation

J Clin Transl Hepatol. 2022 Apr 28;10(2):363-373. doi: 10.14218/JCTH.2021.00219. Epub 2022 Jan 4.


Omics data address key issues in liver transplantation (LT) as the most effective therapeutic means for end-stage liver disease. The purpose of this study was to review the current application and future direction for omics in LT. We reviewed the use of multiomics to elucidate the pathogenesis leading to LT and prognostication. Future directions with respect to the use of omics in LT are also described based on perspectives of surgeons with experience in omics. Significant molecules were identified and summarized based on omics, with a focus on post-transplant liver fibrosis, early allograft dysfunction, tumor recurrence, and graft failure. We emphasized the importance omics for clinicians who perform LTs and prioritized the directions that should be established. We also outlined the ideal workflow for omics in LT. In step with advances in technology, the quality of omics data can be guaranteed using an improved algorithm at a lower price. Concerns should be addressed on the translational value of omics for better therapeutic effects in patients undergoing LT.

Keywords: EAD; Liver transplantation; Metabolomics; Multiomic analysis; Proteomics; Transcriptomics.

Publication types

  • Review