Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjects

J Travel Med. 2022 Jul 14;29(4):taac058. doi: 10.1093/jtm/taac058.
No abstract available

Keywords: Malarone; atovaquone; drug–drug interactions; ketoconazole; malaria chemoprophylaxis; pharmacokinetics; proguanil.

MeSH terms

  • Antimalarials* / adverse effects
  • Atovaquone / adverse effects
  • Drug Combinations
  • Healthy Volunteers
  • Humans
  • Ketoconazole / adverse effects
  • Malaria, Falciparum* / drug therapy
  • Proguanil / adverse effects

Substances

  • Antimalarials
  • Drug Combinations
  • atovaquone, proguanil drug combination
  • Ketoconazole
  • Proguanil
  • Atovaquone