Ketoconazole increases atovaquone exposure following concomitant administration with Malarone® in healthy subjects

J Travel Med. 2022 Jul 14;29(4):taac058. doi: 10.1093/jtm/taac058.

¹ Principal PK Scientist, Quantitative Pharmacology & Pharmacometrics, Early Phase Services, ICON Clinical Research, Reading, UK.
² Department of Clinical Sciences, Karolinska Institute, Stockholm, Sweden.
³ Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, Sahlgrenska Academy at University of Gothenburg, Sweden.
⁴ Dalarna University College, Falun, Sweden.
⁵ Division of Parasitology, Department of Microbiology Tumour and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden.
⁶ Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden.

No abstract available

Keywords: Malarone; atovaquone; drug–drug interactions; ketoconazole; malaria chemoprophylaxis; pharmacokinetics; proguanil.

MeSH terms