Pedigree in the biparental Moran model

J Math Biol. 2022 May 9;84(6):51. doi: 10.1007/s00285-022-01752-0.

Abstract

Our goal is to study the genetic composition of a population in which each individual has 2 parents, who contribute equally to the genome of their offspring. We use a biparental Moran model, which is characterized by its fixed number N of individuals. We fix an individual and consider the proportions of the genomes of all individuals living n time steps later, that come from this individual. When n goes to infinity, these proportions all converge almost surely towards the same random variable. When N then goes to infinity, this random variable multiplied by N (i.e. the stationary weight of any ancestor in the whole population) converges in law towards the mixture of a Dirac measure in 0 and an exponential law with parameter 1/2, and the weights of several given ancestors are independent. This gives an explicit formula for the limiting (deterministic) distribution of all ancestors' weights.

Keywords: Ancestor’s genetic contribution; Biparental Moran model; Genealogy; Large population size limit; Pedigree; Stationary distribution; k-particle Markov chain.

MeSH terms

  • Genetics, Population
  • Genome*
  • Humans
  • Models, Genetic*
  • Pedigree