Three-hour volume of distribution method: an accurate simplified method of glomerular filtration rate measurement

J Nucl Med. 1987 Apr;28(4):510-3.

Abstract

Eight hundred studies of glomerular filtration rate (GFR) measurements were performed by the standard slope-intercept method using [99mTc]DTPA and results were compared with a simultaneous measurement of the 3-hr tracer volume of distribution. A wide range of human renal function was studied and a nonlinear relationship between GFR and the volume of distribution resulted with an excellent correlation (r = 0.989). Agreement between the two measured parameters was not constant for all levels of renal function with the greatest accuracy being found for GFR = 60 to 100 ml/min.

Publication types

  • Comparative Study

MeSH terms

  • Blood Volume
  • Glomerular Filtration Rate*
  • Humans
  • Kidney / metabolism*
  • Kidney Transplantation
  • Metabolic Clearance Rate
  • Organometallic Compounds* / metabolism
  • Pentetic Acid* / metabolism
  • Regression Analysis
  • Retrospective Studies
  • Technetium Tc 99m Pentetate

Substances

  • Organometallic Compounds
  • Pentetic Acid
  • Technetium Tc 99m Pentetate