A continuous-flow protocol for photoredox-catalyzed multicomponent Petasis reaction

Monica Oliva; Frederick Martens; Erik V Van der Eycken; Upendra Kumar Sharma

doi:10.1016/j.xpro.2022.101162

A continuous-flow protocol for photoredox-catalyzed multicomponent Petasis reaction

STAR Protoc. 2022 Feb 5;3(1):101162. doi: 10.1016/j.xpro.2022.101162. eCollection 2022 Mar 18.

Authors

Monica Oliva¹, Frederick Martens¹, Erik V Van der Eycken^{1

2}, Upendra Kumar Sharma¹

Affiliations

¹ Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
² Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, Moscow 117198, Russia.

Abstract

Here, we present a robust protocol for the facile and rapid synthesis of functionalized secondary amines in continuous flow. More specifically, we describe a detailed guide to perform a photocatalyzed Petasis reaction within 50 min using alkyl boronic acid as radical precursor and a Vapourtec E-series as key equipment. The desired functionalized amine has been synthesized in mmol scale and with a productivity rate of 0.2 mmol/h. The protocol is limited to alkyl boronic acids. For complete details on the generation and use of this protocol, please refer to Oliva et al. (2021).

Keywords: Chemistry; Environmental sciences.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes*
Amines*
Boronic Acids
Catalysis

Substances

Aldehydes
Amines
Boronic Acids