Who prescribes quetiapine in Denmark?

Br J Clin Pharmacol. 2022 Sep;88(9):4224-4229. doi: 10.1111/bcp.15388. Epub 2022 May 19.


The second-generation antipsychotic quetiapine is commonly used off-label for its anxiolytic and hypnotic properties. However, quetiapine is associated with problematic side-effects. We used Danish Medicinal Product Statistics and a 20% random sample of the Danish population's prescription fills (2001-2020) to describe the utilization of quetiapine and proportion of various prescriber types (general practitioner [GP], specialist in private practice, hospital physician and other prescribers) both in connection to first-time and subsequent prescriptions. In 2020, 92% of all quetiapine was dispensed outside hospitals and the average daily dispensed quantity of quetiapine per user corresponded to 100 mg/user/d. A GP issued 53% of first-time prescriptions and 75% of subsequent prescriptions for quetiapine in 2020. The proportion of quetiapine prescriptions issued by GPs varied by age group-from 14% among 0-17-year-olds to 93% among the ≥80-year-olds. Future initiatives on the rational use of quetiapine and related drugs, especially among adults, should target GPs.

Keywords: antipsychotics; off-label; prescriber; quetiapine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents* / adverse effects
  • Denmark
  • General Practitioners*
  • Humans
  • Practice Patterns, Physicians'
  • Quetiapine Fumarate / adverse effects


  • Antipsychotic Agents
  • Quetiapine Fumarate