Intracellular mono-ADP-ribosyltransferases at the host-virus interphase

Cell Mol Life Sci. 2022 May 10;79(6):288. doi: 10.1007/s00018-022-04290-6.


The innate immune system, the primary defense mechanism of higher organisms against pathogens including viruses, senses pathogen-associated molecular patterns (PAMPs). In response to PAMPs, interferons (IFNs) are produced, allowing the host to react swiftly to viral infection. In turn the expression of IFN-stimulated genes (ISGs) is induced. Their products disseminate the antiviral response. Among the ISGs conserved in many species are those encoding mono-ADP-ribosyltransferases (mono-ARTs). This prompts the question whether, and if so how, mono-ADP-ribosylation affects viral propagation. Emerging evidence demonstrates that some mono-ADP-ribosyltransferases function as PAMP receptors and modify both host and viral proteins relevant for viral replication. Support for mono-ADP-ribosylation in virus-host interaction stems from the findings that some viruses encode mono-ADP-ribosylhydrolases, which antagonize cellular mono-ARTs. We summarize and discuss the evidence linking mono-ADP-ribosylation and the enzymes relevant to catalyze this reversible modification with the innate immune response as part of the arms race between host and viruses.

Keywords: ADP-ribosylation; Alphavirus; Chikungunya virus; Coronavirus; Hydrolase; Interferon; MARylation; Macrodomain; PARP; Pattern recognition receptors; Signaling.

Publication types

  • Review

MeSH terms

  • ADP Ribose Transferases*
  • Interphase
  • Pathogen-Associated Molecular Pattern Molecules
  • Virus Replication
  • Viruses*


  • Pathogen-Associated Molecular Pattern Molecules
  • ADP Ribose Transferases