The biological effects that glycans elicit are frequently dependent on recognition of specific glycan features by the proteins with which they interact. In this chapter, some of the key structural features underlying glycan–protein interactions, as well as the primary experimental methods that have led to an understanding of these features, are discussed, specifically X-ray crystallography, nuclear magnetic resonance (NMR), cryo-electron microscopy, and computational modeling.
Copyright © 2022 The Consortium of Glycobiology Editors, La Jolla, California; published by Cold Spring Harbor Laboratory Press; doi:10.1101/glycobiology.4e.30. All rights reserved.