The effect of COVID-19 vaccine on ovarian reserve

Saudi Med J. 2022 May;43(5):486-490. doi: 10.15537/smj.2022.43.5.20220007.


Objectives: To Evaluate the effect of messenger ribonucleic acid (mRNA) vaccines developed for the coronavirus disease-19 (COVID-19) on ovarian reserve.

Methods: This prospective cross sectional study was carried out between June and September 2021, in the Gynecology Polyclinics of a tertiary hospital, Ankara, Turkey, with 60 patients. Patients between the ages of 25-30 years old, who applied to the gynecology outpatient clinic and who were considering mRNA vaccination against severe acute respiratory syndrome coronavirus 2 were included in the study group, and those who did not plan to be vaccinated were included in the control group. Anti-müllerian hormone (AMH) was examined before vaccination (1-5 days before vaccination) and within 60-90 days after vaccination. In the unvaccinated group, AMH was examined once.

Results: The mean age of the study group was 27.30±1.66 and of the control group was 27.40±1.69 (p<0.05). Post-vaccine AMH values of the study and control groups were similar (p>0.05). There was no statistically significant difference between pre-vaccine and post-vaccine AMH values in the study group (p>0.05).

Conclusion: It is of great value that people who are planning pregnancy and who have hesitation regarding the effect of vaccines on ovarian reserve should be carefully informed that vaccines, which are one of the most important means of fighting against COVID-19 infection, have no effect on AMH levels. Prospective larger studies with a longer follow-up period are needed to confirm our results.

Keywords: AMH; COVID-19; mRNA; ovarian reserve; vaccine.

MeSH terms

  • Adult
  • Anti-Mullerian Hormone
  • COVID-19 Vaccines / adverse effects
  • COVID-19* / prevention & control
  • Cross-Sectional Studies
  • Female
  • Humans
  • Ovarian Reserve*
  • Pregnancy
  • Prospective Studies
  • RNA, Messenger


  • COVID-19 Vaccines
  • RNA, Messenger
  • Anti-Mullerian Hormone