Glycemic control among children with type 1 diabetes mellitus and its determinants in a resource-limited setting

J Pediatr Endocrinol Metab. 2022 May 12;35(6):813-817. doi: 10.1515/jpem-2022-0144. Print 2022 Jun 27.

Abstract

Objectives: Glycemic control is an important parameter that can predict long-term complications of diabetes mellitus. It can be affected by many factors. Hence, identifying those factors for improving disease outcomes is essential. The purpose of this study was to assess glycemic control in children who were treated with a conventional insulin regimen and to identify its associated factors.

Methods: A retrospective cohort study was conducted among children with type one diabetes mellitus (T1DM) who had follow-up from November 2015 to November 2020 at the pediatric endocrinology clinic of St. Paul's Hospital Millennium Medical College in Addis Ababa, Ethiopia. Glycemic control was assessed by measuring glycosylated hemoglobin (HbA1C) and children who had HbA1C within three to six months of the data collection were recruited.

Results: A total of 106 children with TIDM who were on conventional insulin therapy were included in this study. Their median age at diagnosis was nine years, 47.2% were females, and 57.5% were from urban areas. The average HbA1c of the children was 9.7%. The majority (85.2%) of the children had poor glycemic control (>7.5%). Younger age, longer disease duration, and urban residence were found to be significant predictors of good glycemic control.

Conclusions: A significant majority of children with T1DM had poor glycemic control. This calls for the need to create access to intensive diabetes care by health authorities and stakeholders to prevent the long-term complications of T1DM.

Keywords: Ethiopia; TIDM; glycemic control.

MeSH terms

  • Blood Glucose
  • Child
  • Diabetes Mellitus, Type 1* / complications
  • Ethiopia / epidemiology
  • Female
  • Glycated Hemoglobin / analysis
  • Glycemic Control
  • Humans
  • Hyperglycemia*
  • Hypoglycemic Agents / therapeutic use
  • Insulin / therapeutic use
  • Male
  • Retrospective Studies

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Insulin