Therapeutic drugs remain of great significance for the absorption of wound blood, the closure of wounds and rapid wound healing. Hence, we propose a novel composite nanofiber membrane with the above characteristics as a wound healing material. We utilize the reaction of calcium ion and alginate gel, sodium alginate (SA) and Rana chensinensis skin peptides (RCSPs) extracted from discarded Rana chensinensis skin; these two natural substances were successfully used to prepare composite nanofibers by coaxial electrospinning. The composite nanofibers are named SA@Ca2+/RCSPs nanofibers. SA@Ca2+/RCSPs nanofibers exhibited that the nanofibers contact with the liquid is unmelted, instead become gel, when compared to nanofibers of does not contain calcium ions, and the absorption rate reached 179.87%. SA@Ca2+/RCSPs nanofibers conform to the quasi-first-order dynamics model and the Ritger-Peppas release model. In vivo wound healing experiments showed that the wound-healing rate of SA@Ca2+/RCSPs nanofiber-treated wounds was 46.65% and 97.46% on days 5 and 15, respectively. In addition, SA@Ca2+/RCSPs nanofibers promoted collagen deposition and enhanced epidermal regeneration. The present study showed that composite nanofibers could quickly undergo hemostasis and effectively promote wound healing.
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