Polyionics have great potential in improving the performance of neural probes by regulating microglial response. With the shrinkage of microelectrode size and increase in device complexity, challenges arise during liquid-based synthesis of polyionic compounds on neural probes. Nanocoatings of polyionics, with highly crosslinked bulk structure and abundant ionic functional groups on the surface, were synthesized using a process combining chemical vapor deposition and free radical polymerization. Both conformal surface engineering of neural microelectrodes and facile tailoring of surface ionic composition was achieved using this single-step vapor-based method. Adhesion of microglia was reduced on all the polyionic modified surfaces after a seven-day in vitro test, and polyionics with mixed charges presented much lower microglial adhesion than surfaces with single charges. Laminin adsorption on polyionics with mixed charges was significantly reduced due to the surface electrical neutrality and the enhanced wettability. These findings provide valuable information towards the development of neural probes with enhanced biocompatibility and signal stability.
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