Abstract
Early research on metallothionein centered on aspects related to a detoxification role. As our understanding of the complex endocrine control that regulates metallothionein gene expression increases, a wider appreciation of a functional role(s) is emerging. Medical implications of control of metallothionein turnover include diagnosis of specific diseases and regulation of its expression as a host defense component.
MeSH terms
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Binding Sites
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Biological Transport
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Carrier Proteins / metabolism
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Free Radicals
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Gene Expression Regulation / drug effects
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Hormones / pharmacology
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Humans
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Inactivation, Metabolic
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Intestinal Absorption
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Lysosomes / physiology
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Menkes Kinky Hair Syndrome / metabolism
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Metallothionein* / metabolism
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Metallothionein* / physiology
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Metals / metabolism
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Metals / poisoning
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Protein Conformation
Substances
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Carrier Proteins
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Free Radicals
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Hormones
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Metals
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Metallothionein