Metallothionein

Proc Soc Exp Biol Med. 1987 Jun;185(2):107-19. doi: 10.3181/00379727-185-42525a.

Abstract

Early research on metallothionein centered on aspects related to a detoxification role. As our understanding of the complex endocrine control that regulates metallothionein gene expression increases, a wider appreciation of a functional role(s) is emerging. Medical implications of control of metallothionein turnover include diagnosis of specific diseases and regulation of its expression as a host defense component.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • Biological Transport
  • Carrier Proteins / metabolism
  • Free Radicals
  • Gene Expression Regulation / drug effects
  • Hormones / pharmacology
  • Humans
  • Inactivation, Metabolic
  • Intestinal Absorption
  • Lysosomes / physiology
  • Menkes Kinky Hair Syndrome / metabolism
  • Metallothionein* / metabolism
  • Metallothionein* / physiology
  • Metals / metabolism
  • Metals / poisoning
  • Protein Conformation

Substances

  • Carrier Proteins
  • Free Radicals
  • Hormones
  • Metals
  • Metallothionein