Objective: To compare the curative effect of panlong needling at Jiaji (EX-B 2) combined with western medication and western medication alone on motor dysfunction in patients with Parkinson's disease (PD) of liver and kidney deficiency.
Methods: A total of 98 patients with PD were randomly divided into an acupuncture and medication group (49 cases, 1 case dropped off) and a western medication group (49 cases,1 case was removed). The patients in the western medication group were given oral of levodopa and benserazide hydrochloride tablets, 125 mg each time, three times a day in the 1st week, and the dose was increased according to the needs of the patients' condition from the 2nd week until 250 mg each time, three times a day, for 16 consecutive weeks. On the basis of the same western medication treatment as the western medication group, panlong needling was applied at Jiaji (EX-B 2) from C2 to L5 in the acupuncture and medication group, once a day, 20 times as a course of treatment, for 4 consecutive courses. The scores of unified Parkinson's disease rating scale (UPDRS-Ⅲ, UPDRS-Ⅳ), TCM symptoms score, and 39-item Parkinson's disease questionnaire (PDQ-39) score were evaluated before treatment, after treatment and during follow-up of 1 month after treatment, respectively. The safety of the two groups was compared.
Results: After treatment and during follow-up, except the PDQ-39 score of the western medication group, the scores of UPDRS-Ⅲ, UPDRS-Ⅳ, TCM syndrome and PDQ-39 were lower than those before treatment in the two groups (P<0.05), and the scores of above indexes in the acupuncture and medication group were lower than those of the western medication group (P<0.05). The total incidence of adverse reactions in the acupuncture and medication group was 10.4% (5/48), which was lower than 29.2% (14/48) in the western medication group (P<0.05).
Conclusion: Panlong needling at Jiaji (EX-B 2) combined with western medication could significantly improve the motor dysfunction and clinical symptoms, improve the quality of life and has high safety, and the efficacy is superior to western medication alone.
目的：比较夹脊盘龙刺联合西药与单纯西药治疗帕金森病（PD）运动功能障碍的疗效。方法：将98例PD患者随机分为针药组（49例，脱落1例）和西药组（49例，剔除1例）。西药组口服多巴丝肼片，首周每次125 mg，每日3次，第2周开始根据病情需要增加剂量，直至每次250 mg，每日3次，连续口服16周。针药组在西药组基础上取C2~L5夹脊穴行夹脊盘龙刺，每日1次，20次为一疗程，连续治疗4个疗程（16周）。分别于治疗前、治疗后及治疗结束后1个月随访评价两组患者帕金森病评定量表（UPDRS-Ⅲ、UPDRS-Ⅳ）评分、中医证候评分、帕金森患者生 活质量问卷（PDQ-39）评分，并比较两组的安全性。结果：治疗后及随访时，除西药组PDQ-39评分外，两组UPDRS-Ⅲ、UPDRS-Ⅳ评分及中医证候评分、PDQ-39评分均较治疗前降低（P<0.05），且针药组均低于西药组（P<0.05）。针药组不良反应总发生率为10.4%（5/48），低于西药组的29.2%（14/48，P<0.05）。结论：夹脊盘龙刺联合西药治疗PD患者疗效优于单纯西药治疗，能明显改善患者运动功能障碍及临床症状，提高患者生活质量，且安全性较高。.
Keywords: Parkinson's disease; Point EX-B 2 (Jiaji); motor dysfunction; panlong needling; randomized controlled trial (RCT).