Antibody Seronegativity in COVID-19 RT-PCR-Positive Children

Pediatr Infect Dis J. 2022 Aug 1;41(8):e318-e320. doi: 10.1097/INF.0000000000003573. Epub 2022 Jul 13.


This substudy of a prospective case-ascertained household transmission study investigated severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction-positive individuals without antibody development and factors associated with nonseroconversion. Approximately 1 of 8 individuals with coronavirus disease 2019 did not seroconvert. Children, particularly the youngest, were approximately half as likely to seroconvert compared with adults. Apart from the absence of fever/chills, individual symptoms did not strongly predict nonseroconversion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies
  • COVID-19* / diagnosis
  • Child
  • Humans
  • Prospective Studies
  • Reverse Transcriptase Polymerase Chain Reaction
  • SARS-CoV-2 / genetics


  • Antibodies

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