Cisapride in non-ulcer dyspepsia. Results of a placebo-controlled trial

Scand J Gastroenterol. 1987 Mar;22(2):161-4. doi: 10.3109/00365528708991874.


The effect of cisapride, 10 mg three times daily, was evaluated in a double-blind randomized study in 118 patients with non-ulcer dyspepsia. Peptic ulcer disease was excluded by endoscopy, gallstones by ultrasonography, and chronic pancreatitis by a series of non-invasive tests. Symptomatic improvement was evaluated by interview after 2 and 4 weeks; the patients also kept a diary. Cisapride caused significant improvement compared with placebo with regard to frequency and severity of symptoms and may therefore be useful in the therapy of non-ulcer dyspepsia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Cisapride
  • Clinical Trials as Topic
  • Double-Blind Method
  • Dyspepsia / diagnosis
  • Dyspepsia / drug therapy*
  • Humans
  • Peptic Ulcer / diagnosis
  • Piperidines / therapeutic use*
  • Random Allocation


  • Piperidines
  • Cisapride