[Controlled study of increasing venous tone in primary varicose veins by oral administration of Ruscus aculeatus and trimethylhespiridinchalcone]

Z Hautkr. 1987 Jan 1;62(1):28-38.
[Article in German]


In a randomized double blind study, 50 patients suffering from trunk or branch varicosis were orally treated with either a commercial preparation of Ruscus extract, trimethyl hesperidine chalcone and ascorbic acid (Phlebodril), or a placebo over 2 weeks. Changes of the venous tonus were measured by means of venous occlusion plethysmography in rest position (venous capacity, venous distensibility) as well as during (active) exercise (expelled blood volume). All parameters showed a tendency towards improvement in the verum group. The changes were partly significant (p less than 0.5). The course of the study suggests that the period of treatment possibly was too short to obtain the full pharmacologic effect.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Chalcone / analogs & derivatives
  • Chalcone / therapeutic use*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Combinations / therapeutic use
  • Female
  • Flavonoids / therapeutic use*
  • Hesperidin / analogs & derivatives
  • Hesperidin / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Plant Extracts / therapeutic use*
  • Plethysmography
  • Propiophenones / therapeutic use*
  • Random Allocation
  • Rheology
  • Varicose Veins / drug therapy*
  • Vascular Resistance / drug effects*
  • Venous Insufficiency / drug therapy


  • Drug Combinations
  • Flavonoids
  • Plant Extracts
  • Propiophenones
  • phlebodril
  • Chalcone
  • Hesperidin