Fusidic acid in acute conjunctivitis. Single-blind, randomized comparison of fusidic acid and chloramphenicol viscous eye drops

Acta Ophthalmol (Copenh). 1987 Feb;65(1):43-7. doi: 10.1111/j.1755-3768.1987.tb08489.x.


Fusidic acid 1% and chloramphenicol 0.5% eye drops were in a randomized, single-blind manner given as a one-week treatment to out-patients with acute, purulent conjunctivitis. A clinical success was recorded in 84% (102/121) of patients receiving fusidic acid and in 81% (104/129) of patients receiving chloramphenicol. More patients (14%) receiving chloramphenicol complained of trivial side effects such as stinging and local discomfort, compared with fusidic acid (5%). No serious side effects were recorded. It is concluded that fusidic acid dispensed in a carbomer eye vehicle represents an effective and well tolerated new topical eye preparation with the advantage of being administered twice daily.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Chloramphenicol / therapeutic use*
  • Clinical Trials as Topic
  • Conjunctivitis / complications
  • Conjunctivitis / drug therapy*
  • Female
  • Fusidic Acid / adverse effects
  • Fusidic Acid / therapeutic use*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Ophthalmic Solutions
  • Random Allocation


  • Ophthalmic Solutions
  • Fusidic Acid
  • Chloramphenicol