Toward Early Diagnosis of Colorectal Cancer: Focus on Optical Nano Biosensors

Abstract

Background: Colorectal cancer is a leading cause of death among cancers worldwide, with the symptoms mimicking other far more common lower gastrointestinal disorders.

Objective: This challenge in separating colorectal cancer from other diseases has driven researchers to investigate a noninvasive screening technique and effective method. The early detection of colorectal cancer is imperative. Biomarkers play a critical role in colorectal screening tests, treatment, clinical and prognosis management. Therefore, sensitive and rapid biomarker detection would be helpful and demand the early diagnosis of colorectal cancer.

Methods: Recently, several investigations have been performed to design biosensors for early detection of cancer diagnosis and profiling with strong applied ability and high sensitivity.

Results: In comparison, optical biosensors are one of the promising platforms for the costeffective and rapid detection of biomarkers. This review will focus on the advancements and progress of the various optical-transducing approaches for diagnosing colorectal cancer.

Conclusion: Further, the prospects and limitations of these optical biosensors in colorectal cancer diagnosis will be discussed. Here, an overview of optical biosensors and meaningful information for scientists worldwide will be demonstrated.

Keywords: Colorectal cancer; biomarkers; biosensor; detection and screening; diagnosis; optical sensor.