Abstract
Hypogonadism is prevalent in patients with renal insufficiency and is manifested as sexual dysfunction and infertility in males and as anovulation and amenorrhea in females. Although many investigators believe that the defect represents primary gonadal damage by uremic toxins, we propose the coexistence of central neuroendocrine disorders in the regulation of gonadotropin secretion. Evidence supporting such a hypothesis is discussed.
MeSH terms
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Erectile Dysfunction / etiology
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Erectile Dysfunction / physiopathology
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Female
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Humans
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Hyperprolactinemia / etiology
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Hyperprolactinemia / physiopathology
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Hypogonadism / etiology
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Hypogonadism / physiopathology
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Infertility, Male / etiology
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Infertility, Male / physiopathology
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Kidney Failure, Chronic / complications
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Kidney Failure, Chronic / physiopathology*
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Male
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Ovary / physiopathology
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Reproduction*
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Spermatogenesis
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Uremia / etiology
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Uremia / physiopathology