ECG changes during haloperidol and pimozide treatment of Tourette's disorder

Am J Psychiatry. 1987 May;144(5):673-5. doi: 10.1176/ajp.144.5.673.

Abstract

The ECG QTc interval was significantly prolonged by pimozide but not haloperidol or placebo in a randomized clinical trial with 40 patients with Tourette's disorder. However, no adverse cardiac effects or differences in rate, rhythm, or waveform were found.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Clinical Trials as Topic
  • Electrocardiography*
  • Female
  • Haloperidol / pharmacology
  • Haloperidol / therapeutic use*
  • Heart / drug effects*
  • Heart Rate / drug effects
  • Humans
  • Male
  • Pimozide / pharmacology
  • Pimozide / therapeutic use*
  • Placebos
  • Random Allocation
  • Tourette Syndrome / drug therapy*

Substances

  • Placebos
  • Pimozide
  • Haloperidol