Abstract
The ECG QTc interval was significantly prolonged by pimozide but not haloperidol or placebo in a randomized clinical trial with 40 patients with Tourette's disorder. However, no adverse cardiac effects or differences in rate, rhythm, or waveform were found.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Clinical Trials as Topic
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Electrocardiography*
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Female
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Haloperidol / pharmacology
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Haloperidol / therapeutic use*
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Heart / drug effects*
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Heart Rate / drug effects
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Humans
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Male
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Pimozide / pharmacology
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Pimozide / therapeutic use*
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Placebos
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Random Allocation
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Tourette Syndrome / drug therapy*
Substances
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Placebos
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Pimozide
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Haloperidol