Comparison of continuous epidural infusion of a local anesthetic and administration of systemic narcotics in the management of pain after total knee replacement surgery

Anesth Analg. 1987 May;66(5):401-6. doi: 10.1213/00000539-198705000-00005.


Continuous bupivacaine epidural analgesia was compared with conventional methods of systemic analgesic administration in the management of postoperative pain in 30 patients for 3 days following total knee replacement surgery. Patients given continuous epidural analgesia had significantly better pain relief (visual analogue scale, global evaluation), needed significantly fewer supplementary analgesics, and had significantly fewer side effects. In the epidural group, sensory block averaged six dermatomes on day 1 and four dermatomes on day 3. The number of patients with complete (or almost complete) motor block of the lower limbs decreased from eight on day 1 to five on day 3. The mean dosage of bupivacaine decreased from 21.0 +/- 5.7 (SD) mg/hr on day 1 to 15.1 +/- 8.5 mg/hr on day 3. No signs of accumulation of or toxic reactions to bupivacaine were seen.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anesthesia, Epidural / adverse effects
  • Anesthesia, Epidural / methods*
  • Bupivacaine / administration & dosage*
  • Clinical Trials as Topic
  • Humans
  • Knee Prosthesis*
  • Meperidine / administration & dosage*
  • Middle Aged
  • Morphine / administration & dosage*
  • Pain, Postoperative / drug therapy*
  • Time Factors


  • Morphine
  • Meperidine
  • Bupivacaine