Nicardipine in the treatment of Raynaud's phenomenon: a randomized double-blind trial

Angiology. 1987 Apr;38(4):333-7. doi: 10.1177/000331978703800407.


The efficacy of the calcium-channel blocker nicardipine in the treatment of Raynaud's phenomenon was assessed in a prospective, double-blind, randomized, crossover trial in 20 patients. Each patient received nicardipine 20 mg or placebo three times a day for two weeks and then was crossed over for two weeks. Nicardipine significantly decreased the frequency and severity of Raynaud's phenomenon as compared with placebo. The authors conclude that nicardipine is effective in the treatment of Raynaud's phenomenon.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nicardipine / adverse effects
  • Nicardipine / therapeutic use*
  • Patient Compliance
  • Placebos
  • Random Allocation
  • Raynaud Disease / drug therapy*


  • Placebos
  • Nicardipine