In Reply: TP53 Alteration Status and Tumor Mutational Burden Score: Prevalence and Prognosis in Head and Neck Squamous Cell Carcinoma

Oncologist. 2022 Jul 5;27(7):e606-e607. doi: 10.1093/oncolo/oyac088.


This Letter to the Editor responds to recent comments by Jiang et al. and joins the recommendation for further investigations into the role of TP53alteration status and TMB as predictors of response to immunotherapy and survival in head and neck squamous cell carcinoma.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Biomarkers, Tumor
  • Head and Neck Neoplasms* / epidemiology
  • Head and Neck Neoplasms* / genetics
  • Humans
  • Prevalence
  • Prognosis
  • Squamous Cell Carcinoma of Head and Neck / genetics
  • Tumor Suppressor Protein p53 / genetics


  • Biomarkers, Tumor
  • TP53 protein, human
  • Tumor Suppressor Protein p53