Endotoxins and disease mechanisms

Annu Rev Med. 1987;38:417-32. doi: 10.1146/annurev.me.38.020187.002221.


In this chapter, current concepts about the mechanisms of action of endotoxin are reviewed. Particular attention is focused upon endotoxin-induced production of soluble mediators from macrophages and mononuclear cells and on the potential contribution of these mediators to endotoxin shock. In many cases, the interrelationships between these mediators as primary and/or secondary consequences of endotoxin stimulation of mononuclear phagocytes are discussed. Final comments address the relevance of these mediators to the therapy of endotoxin shock.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Endotoxins* / metabolism
  • Humans
  • Shock, Septic / etiology*
  • Shock, Septic / metabolism


  • Endotoxins