Barrett's esophagus and adenocarcinoma

Annu Rev Med. 1987;38:477-92. doi: 10.1146/


Barrett's esophagus represents an epithelial metaplasia in which a columnar lining replaces normal squamous epithelium of the esophagus. It occurs in at least 10% of patients with chronic gastroesophageal reflux and is associated with an increased risk of adenocarcinoma of the esophagus. This review focuses on the criteria for the diagnosis of Barrett's esophagus, discusses its association with adenocarcinoma, and provides guidelines for surveillance for carcinoma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma / etiology*
  • Adult
  • Aged
  • Aged, 80 and over
  • Barrett Esophagus / complications
  • Barrett Esophagus / diagnosis*
  • Esophageal Diseases / diagnosis*
  • Esophageal Neoplasms / etiology*
  • Female
  • Humans
  • Middle Aged