Calcium and vitamin D modulate mouse colon epithelial proliferation and growth characteristics of a human colon tumor cell line

Can J Physiol Pharmacol. 1987 Mar;65(3):472-7. doi: 10.1139/y87-081.


The role of calcium and vitamin D in the prevention of colorectal cancer is only now being investigated at the organismal, cellular, and molecular biologic levels. Recent epidemiologic studies have supported the hypothesis that dietary calcium and vitamin D may be related to a reduced risk for colon cancer. The evidence from laboratory investigations in animals and in cell culture also indicate a possible preventative effect. Addition of calcium and vitamin D to the roster of developmental cancer chemopreventative agents for further research is warranted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Calcium / therapeutic use
  • Cell Division
  • Cell Line
  • Colon / pathology*
  • Colonic Neoplasms / pathology*
  • Colonic Neoplasms / prevention & control
  • Epithelium / pathology
  • Humans
  • Intestinal Mucosa / pathology
  • Mice
  • Vitamin D / physiology*
  • Vitamin D / therapeutic use


  • Vitamin D
  • Calcium