Is bicarbonate therapy effective in preventing CKD progression?

J Fam Pract. 2022 Apr;71(3):E15-E16. doi: 10.12788/jfp.0377.


YES. Long-term sodium bicarbonate therapy slightly slows the loss of renal function in patients with chronic kidney disease (CKD) and may moderately reduce progression to end-stage renal disease (strength of recommendation [SOR]: B, meta-analyses of lower-quality randomized controlled trails [RCTs]). Therapy duration of 1 year or less may not be beneficial (SOR: C, secondary analyses in meta-analyses).

MeSH terms

  • Bicarbonates
  • Disease Progression
  • Female
  • Humans
  • Kidney Failure, Chronic* / drug therapy
  • Kidney Failure, Chronic* / prevention & control
  • Male
  • Renal Insufficiency, Chronic* / drug therapy
  • Sodium Bicarbonate / therapeutic use


  • Bicarbonates
  • Sodium Bicarbonate