Coronary Artery Ectasia: Review of the Non-Atherosclerotic Molecular and Pathophysiologic Concepts

Int J Mol Sci. 2022 May 6;23(9):5195. doi: 10.3390/ijms23095195.


Coronary artery ectasia (CAE) is frequently encountered in clinical practice, conjointly with atherosclerotic CAD (CAD). Given the overlapping cardiovascular risk factors for patients with concomitant CAE and atherosclerotic CAD, a common underlying pathophysiology is often postulated. However, coronary artery ectasia may arise independently, as isolated (pure) CAE, thereby raising suspicions of an alternative mechanism. Herein, we review the existing evidence for the pathophysiology of CAE in order to help direct management strategies towards enhanced detection and treatment.

Keywords: CAD; coronary artery aneurysm; coronary artery ectasia; cytokine; lipidome.

Publication types

  • Review

MeSH terms

  • Coronary Angiography
  • Coronary Artery Disease* / diagnosis
  • Coronary Vessels*
  • Dilatation, Pathologic
  • Humans

Grants and funding

This research received no external funding.