Ventilatory effects of inhaled capsaicin in man

Eur J Clin Pharmacol. 1987;31(6):715-7. doi: 10.1007/BF00541301.


Nebulised capsaicin (10(-7) M) was inhaled by 8 normal subjects to study its effects on the pattern of breathing. When compared to the diluent alone capsaicin increased mean inspiratory flow, a reflection of central inspiratory drive (mean increase: 25 +/- 6%, SEM, p less than 0.01), with a trend to increasing ventilation through more rapid but not more shallow breathing. If capsaicin selectively stimulates non-myelinated fibres in the lung in man as it does in dogs, these results suggest that such stimulation in man can alter the pattern of breathing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aerosols
  • Bronchi / drug effects
  • Capsaicin / administration & dosage
  • Capsaicin / pharmacology*
  • Female
  • Humans
  • Respiration / drug effects*
  • Respiratory Function Tests


  • Aerosols
  • Capsaicin