[Mechanism of action of piracetam on cerebral circulation]

Farmakol Toksikol. Jan-Feb 1987;50(1):38-41.
[Article in Russian]

Abstract

The experimental data show that piracetam exerts a marked effect on cerebral hemodynamics producing a lowering of cerebral artery tonus and an increase of local blood flow. In addition, an increase of GABA content is noted, particularly following an experimentally-induced disorder of cerebral blood circulation. A stable dilatation of the mean capillary diameter, a decrease of the number of non-functioning capillaries in the brain cortex after piracetam administration indicate an important role of piracetam as a cyclic analogue of GABA in regulation and compensation of disordered cerebral hemodynamics.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Brain / metabolism
  • Cats
  • Cerebrovascular Circulation / drug effects*
  • Cerebrovascular Disorders / physiopathology
  • Piracetam / pharmacology*
  • Pyrrolidinones / pharmacology*
  • Rats
  • Time Factors
  • Vascular Resistance / drug effects
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Pyrrolidinones
  • gamma-Aminobutyric Acid
  • Piracetam