[Search for anti-inflammatory preparations among the derivatives of succinic acid heteryl amides]

V I Kabachnyĭ; V P Chernykh; S M Drogovoz; Iu A Golubenko; E E Bogutskaia

[Search for anti-inflammatory preparations among the derivatives of succinic acid heteryl amides]

Farmakol Toksikol. 1987 Jan-Feb;50(1):94-7.

[Article in Russian]

Authors

V I Kabachnyĭ, V P Chernykh, S M Drogovoz, Iu A Golubenko, E E Bogutskaia

PMID: 3556563

Abstract

The antiinflammatory activity and acute toxicity of 44 derivatives of heteryl amides of succinic acid (acids, esters, amides) were studied. This series of compounds was found to be promising for the search of nonsteroidal, practically nontoxic antiphlogistics. The structural-pharmacological analysis was performed and the dependence of the biological effect on the compound structure was revealed.

Publication types

Comparative Study
English Abstract

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Drug Evaluation, Preclinical
Edema / chemically induced
Edema / drug therapy
Formaldehyde
Inflammation / chemically induced
Inflammation / drug therapy
Mice
Structure-Activity Relationship
Succinates / therapeutic use*
Time Factors

Substances

Anti-Inflammatory Agents, Non-Steroidal
Succinates
Formaldehyde