Intestinal Barrier Permeability in Allergic Diseases

Nutrients. 2022 Apr 30;14(9):1893. doi: 10.3390/nu14091893.


The role of intestinal permeability (IP) markers among children and adults with food allergies is not fully understood, and the identification of biological indicators/markers that predict growth retardation in children with allergic diseases and atopy has not been well explained. Studies have shown that patients with atopic diseases respond abnormally to food allergens. Accordingly, differences in the types of immune complexes formed in response to antigen challenges are significant, which seems to underlie the systemic signs of the food allergy. Increased intestinal permeability over the course of a food allergy allows allergens to penetrate through the intestinal barrier and stimulate the submucosal immune system. Additionally, the release of cytokines and inflammatory mediators enhances the degradation of the epithelial barrier and leads to an improper cycle, resulting in increased intestinal permeability. Several studies have also demonstrated increased permeability of the epithelial cells in those afflicted with atopic eczema and bronchial asthma. Ongoing research is aimed at finding various indicators to assess IP in patients with atopic diseases.

Keywords: children; dysbiosis; food allergy; microbiome; tight junctions.

Publication types

  • Review

MeSH terms

  • Allergens
  • Child
  • Dermatitis, Atopic*
  • Food Hypersensitivity*
  • Humans
  • Intestines
  • Permeability


  • Allergens

Grants and funding

This research received no external funding.